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Istituto di Ricerche Farmacologiche Mario
Negri, Milan, Italy. pelucchi@marionegri.it
Dietary
fibre has been reported to protect from several
neoplasms, but the issue remains controversial.
No previous study considered in depth the
topic of fibres and prostate cancer. A multicentre
case-control study was conducted in Italy
from 1991 to 2002, including 1,294 men with
incident, histologically confirmed prostate
cancer and 1,451 controls admitted to the
same network of hospitals as cases with acute
nonmalignant conditions.
Multivariate odds
ratios (OR) and 95% confidence intervals
(CI) were obtained after allowance for major
identified confounding factors, including
total energy intake.
Compared to the lowest
quintile, the OR of prostate cancer for the
highest quintile of total fibre intake was
0.93 (95% CI 0.71-1.22). The risk was inversely
related with soluble fibre (OR = 0.89, 95%
CI 0.78-1.02, for a difference between 80th
and 20th percentile), cellulose (OR = 0.88,
95% CI 0.78-1.01) and vegetable fibre (OR
= 0.82, 95% CI 0.73-0.93).
These relationships
were consistent across strata of age, family
history of prostate cancer, body mass index
and education. Vegetable fibres appear, therefore,
to have a favourable association with prostate
cancer risk. Copyright 2003 Wiley-Liss, Inc.
PMID: 14750181 [PubMed - indexed for MEDLINE] |
